Gilbert Blythe is finally a doctor, and at long last he and Anne are ready to say their vows. Soon husband and wife will be bound for a new life together in their own house of dreams, on the shores of Four Winds Harbor, near Gilbert's new medical practice in the village of Glen St. Mary.

Of course, a new life brings fresh surprises and fresh problems to solve. Anne and Gilbert soon find themselves entangled in the lives of their neighbors, including the lighthouse attendant, Captain Jim, with his sad stories of the sea; Miss Cornelia Bryant, a formidable woman who always speaks her mind; Owen Ford, who longs to write the Great Canadian Novel; and the tragically beautiful Leslie Moore, to whom Anne grows closer when her own perfect life is touched by heartbreak.